AHA Journals Null Hypothesis Collection

Publishing research with negative results—that is, null or inconclusive findings—is a critical but often overlooked task of biomedical journals. Without it, the scientific literature relies on highly selected pieces of evidence that viewed in isolation can distort a field. Together we can address publication bias by encouraging the write-up and publication of all well-performed studies. Doing so not only improves research culture and enhances research efficiency but reduces the risk of avoidable harm to patients by ensuring that clinical practice is informed by a more complete and balanced record.

As part of an ongoing effort to promote research transparency, the AHA Journals and Wolters Kluwer have entered into an agreement with the Center for Biomedical Research Transparency (CBMRT) to create an online Null Hypothesis Collection highlighting important and impactful articles from across the portfolio that report on negative, inconclusive, or confirmatory research. CBMRT has agreed to provide financial support to make select articles freely available online and will help promote the initiative through their channels. We hope the Null Hypothesis Collection will be an important vehicle for promoting more balance in our publications.

For more on this initiative, see the introductory article, "True Negatives: Disseminating Research on Null, Inconclusive, and Confirmatory Findings in Cardiovascular Science."

• March 25, 2022

  Intensive Versus Standard Treatment of Hyperglycemia in Acute Ischemic Stroke Patient: A Randomized Clinical Trial Subgroups Analysis

  • Michel T. Torbey,
  • Qi Pauls,
  • Nina Gentile,
  • Mercedes Falciglia,
  • William Meurer,
  • Creed L. Pettigrew,
  • Valerie L. Durkalski,
  • Thomas Bleck,
  • Askiel Bruno and

  for the Neurological Emergencies Treatment Trials Network and SHINE Trial Investigators

  Stroke

• November 3, 2021

  Hospital Readmissions and Mortality Among Fee‐for‐Service Medicare Patients With Minor Stroke or Transient Ischemic Attack: Findings From the COMPASS Cluster‐Randomized Pragmatic Trial

  • Cheryl D. Bushnell,
  • Anna M. Kucharska‐Newton,
  • Sara B. Jones,
  • Matthew A. Psioda,
  • Anna M. Johnson,
  • Laurie C. Daras,
  • Jacqueline R. Halladay,
  • Janet Prvu Bettger,
  • Janet K. Freburger,
  • Sabina B. Gesell,
  • Sylvia W. Coleman,
  • Mysha E. Sissine,
  • Fang Wen,
  • Gary P. Hunt,
  • Wayne D. Rosamond and
  • Pamela W. Duncan

  Journal of the American Heart Association

• September 24, 2021

  Effect of Posting on Social Media on Systolic Blood Pressure and Management of Hypertension: A Randomized Controlled Trial

  • Christina Mancheno,
  • David A. Asch,
  • Elissa V. Klinger,
  • Jesse L. Goldshear,
  • Nandita Mitra,
  • Alison M. Buttenheim,
  • Frances K. Barg,
  • Lyle H. Ungar,
  • Lin Yang and
  • Raina M. Merchant

  Journal of the American Heart Association

• August 30, 2021

  Patent Foramen Ovale Closure Decreases the Incidence but Not the Size of New Brain Infarction on Magnetic Resonance Imaging: An Analysis of the REDUCE Trial

  • Steven R. Messé,
  • Guray Erus,
  • Michel Bilello,
  • Christos Davatzikos,
  • Grethe Andersen,
  • Helle K. Iversen,
  • Risto O. Roine,
  • Christina Sjöstrand,
  • John F. Rhodes,
  • Lars Søndergaard,
  • Scott E. Kasner and

  on behalf of the Gore REDUCE Study Investigators

  Stroke

• August 5, 2021

  Roxadustat Does Not Affect Platelet Production, Activation, and Thrombosis Formation

  • Jiaxin Zhao,
  • Yanyan Xu,
  • Jingyuan Xie,
  • Junling Liu,
  • Ruiyan Zhang and
  • Xiaoxiang Yan

  Arteriosclerosis, Thrombosis, and Vascular Biology

• May 16, 2021

  Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy (PRADA): Extended Follow-Up of a 2×2 Factorial, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of Candesartan and Metoprolol

  • Siri Lagethon Heck,
  • Albulena Mecinaj,
  • Anne Hansen Ree,
  • Pavel Hoffmann,
  • Jeanette Schulz-Menger,
  • Morten Wang Fagerland,
  • Berit Gravdehaug,
  • Helge Røsjø,
  • Kjetil Steine,
  • Jürgen Geisler,
  • Geeta Gulati and
  • Torbjørn Omland

  Circulation

• January 4, 2021

  Direct Actions of AT₁ (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy

  • Matthew A. Sparks,
  • Fitra Rianto,
  • Edward Diaz,
  • Ritika Revoori,
  • Thien Hoang,
  • Lucas Bouknight,
  • Johannes Stegbauer,
  • Anuradha Vivekanandan-Giri,
  • Phillip Ruiz,
  • Subramaniam Pennathur,
  • Dennis M. Abraham,
  • Susan B. Gurley,
  • Steven D. Crowley and
  • Thomas M. Coffman

  Hypertension

• December 29, 2020

  Association Between Frailty and Atrial Fibrillation in Older Adults: The Framingham Heart Study Offspring Cohort

  • Ariela R. Orkaby,
  • Jelena Kornej,
  • Steven A. Lubitz,
  • David D. McManus,
  • Thomas G. Travison,
  • Jason A. Sherer,
  • Ludovic Trinquart,
  • Joanne M. Murabito,
  • Emelia J. Benjamin and
  • Sarah R. Preis

  Journal of the American Heart Association

• December 10, 2020

  Jugular Vein Injection of High-Titer Lentiviral Vectors Does Not Transduce the Aorta—Brief Report

  • Lianxiang Bi(毕联祥),
  • Bradley K. Wacker,
  • Alexis Stamatikos,
  • Meena Sethuraman,
  • Kaushik Komandur and
  • David A. Dichek

  Arteriosclerosis, Thrombosis, and Vascular Biology

• September 24, 2020

  The Heart Failure Readmission Intervention by Variable Early Follow-up (THRIVE) Study

  • Keane K. Lee,
  • Rachel C. Thomas,
  • Thida C. Tan,
  • Thomas K. Leong,
  • Anthony Steimle and
  • Alan S. Go

  Circulation: Cardiovascular Quality and Outcomes